Selection of the optimal composition of vegetable oil and chlorophyllipt oil components


  • R. M. Sachuk Research Epizootology Station IVM NAAS, Knyazya Volodymyra Str., 18, Rivne, 33028, Ukraine https://orcid.org/0000-0003-4532-4220
  • Ya. S. Stravsky I. Horbachevsky Ternopil National Medical University, Freedom Square, 1, Ternopil, 46001, Ukraine
  • YU. V. Horyuk State Agrarian and Technical University Podilіа, Schevchenko Str., 13, Kamianets-Podilskyi, 32300, Ukraine https://orcid.org/0000-0002-7162-8992
  • O. A. Katsaraba Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Pekarska, Str., 50, Lviv, 79010, Ukraine https://orcid.org/0000-0001-8520-224X
  • S. V. Zhyhalyuk Research Epizootology Station IVM NAAS, Knyazya Volodymyra Str., 18, Rivne, 33028, Ukraine
Keywords: essential oils, chlorophyllipt, clindamycin, antimicrobial activity, test cultures, skin

Abstract

Investigate the antimicrobial properties of various concentrations of vegetable essential oils in combination with an oil solution of chlorophyllipt as possible ingredients for ointments for wounds. Microbiological tests were performed according to standard methods using E. coli test cultures, S. aureus, Str. agalactiae and P. fluorescens. The results of studies of antibacterial activity of both individual ingredients and their combinations are presented, namely: 4 % essential oil of Siberian pine, 2 % essential oil of eucalyptus, 1.5 % essential oil of cloves, 1.5 % of essential oil of cedar, 2.0 % tea tree essential oil and 1.0 % chlorophyllipt oil solution. Bacteria, which are usually typical agents of wound infections, have been found to be quite sensitive to the drugs tested. High activity of essential oils and oily solution of chlorophyllipt with respect to E. coli and S. aureus was revealed. In particular, a 1.0 % oily solution of chlorophyllipt caused staphylococcal growth retardation zones whose diameters were 1.4 times larger than the antibiotic clindamycin. It was determined that representatives of gram-negative microflora were more sensitive to the investigated essential oils and chlorophyll. The optimal composition of the experimental drug called “Ointment for wounds” is offered. The results of preclinical testing showed a sufficiently high efficiency compared to traditional means. The results obtained with regard to antimicrobial activity indicate the prospect of using preparations based on the essential oil of Siberian pine, eucalyptus, carnation, cedar, tea tree and oil solution of chlorophyllipt for the treatment of skin diseases in animals. This data will help to develop new effective and safe veterinary treatments for wound care.

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Ukrainian Journal of Veterinary and Agricultural Sciences, 2019, Vol. 2, N 3 14

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Published
2019-12-03
How to Cite
Sachuk, R., Stravsky, Y., Horyuk, Y., Katsaraba, O., & Zhyhalyuk, S. (2019). Selection of the optimal composition of vegetable oil and chlorophyllipt oil components. Ukrainian Journal of Veterinary and Agricultural Sciences, 2(3), 11-14. https://doi.org/https://doi.org/10.32718/ujvas2-3.03