Biochemical indices of piglets blood under the action of feed additive “Butaselmevit-plus”

Keywords: piglets, oxidative stress, “Butaselmevit-plus” feed additive, blood, enzymes, proteins


The purpose of the search was to investigate the influence of feed additive “Butaselmevit-plus” on the biochemical indices of piglets blood when weaned. The experiments were conducted on the basis of Ltd. “KOSHET” of Mukachevo district, Transcarpathian region. Two groups of pigs were formed – control (C) and experimental (E), in the number of 10 individuals in each group, selected on the basis of analogues – age, breed and body weight. In the suckling period, pigletss were kept under sows in special machines, had constant access to the mother, and from 5 days of age – free access to concentrated feed. The research material was blood collected in the morning by puncture of the cranial vena cava on the 20th day of life (period before weaning), on the 25th day of life (period before weaning), on the 30th day of life (2 days after weaning), for 35 days of life (7 days after weaning), for 40 days of life (12 days after weaning). Weaning of piglets from sows at 28 days of age leads to a slight decrease in total protein and increased activity of aminotransferases. Increased activity of ALAT and ASAT in pigs' serum after weaning from sows reflects the nonspecific response of the organism to the action of stress factors and indicates an increased release of enzymes into the extracellular space. Feeding of piglets with feed additives “Butaselmevit-plus” promotes to enhance the protein synthesizing function of the liver and reduce the activity of aminotransferases. The decrease in the activity of aminotransferases in the blood of piglets of the experimental group, indicates that the components of the feed additive counteract the influence of stress, and also contribute to the maintenance the integrity of cell membranes specific to these organ enzymes, which prevents their output from the cells.


Ahmad, M. K., Amani, S., & Mahmood, R. (2011). Potassium bromate causes cell lysis and induces oxidative stress in hu-manerythrocytes. Environmental Toxicology, 29(2), 138–145. doi: 10.1002/tox.20780.

Chala, I. V., & Rusak, V. S. (2016). Redox–potential and the state of peroxide oxidation of blood lipids in cows kept under ecolog-ically unfavorable conditions. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj, 18, 2(66), 197–201. doi: 10.15421/nvlvet6640.

Cherkashina, D. V., & Petrenko, A. Y. (2006). Hepatoprotective effect of fetal tissue cytosol and its thermostable fraction in rats with carbon tetrachloride-induced hepatitis. B. Exp. Biol. Med., 141(4), 544–547. doi: 10.1007/s10517-006-0216-y.

Gutyj, B., Martyshchuk, T., Bushueva, I., Semeniv, B., Parchenko, V., Kaplaushenko, A., Magrelo, N., Hirkovyy, A., Musiy, L., & Murska, S. (2017). Morphological and biochemical indicators of blood of rats poisoned by carbon tetrachloride and subject to ac-tion of liposomal preparation. Regulatory Mechanisms in Bio-systems, 8(2), 304–309. doi: 10.15421/021748.

Gutyj, B., Stybel, V., Hariv, I., Maksymovych, I., Buczek, K., Staniec, M., Milczak, A., Bushueva, I., Kulish, S., Shcherbyna, R., & Samura, T. (2019). Influence Of Amprolinsile And Bro-vitacoccid On The Protein Synthesizing Function Of The Liver And Enzyme Activity In Turkey Blood Serum During Eimeria Invasion. Research Journal of Pharmaceutical, Biological and Chemical Sciences, 10(2), 723–729. pdf/2019_10(2)/[99].pdf.

Khariv, I., Gutyj, B., Hunchak, V., Slobodyuk, N., Vynyarska, A., Sobolta, A., Todoriuk, V., & Seniv, R. (2017). The influence of brovitatoxide in conjunction with milk thistle fruits on the im-mune system of turkeys for eimeriozic invasion. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj, 19(73), 163–168. doi: 10.15421/nvlvet7334.

Khariv, M., Gutyj, B., Butsyak, V., & Khariv, I. (2016). Hematolog-ical indices of rat organisms under conditions of oxidative stress and liposomal preparation action. Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University, 6(1), 276–289. doi: 10.15421/201615.

Khariv, M., Gutyj, B., Ohorodnyk, N., Vishchur, O., Khariv, I., Solovodzinska, I., Mudrak, D., Grymak, C., & Bodnar, P. (2017). Activity of the T- and B-system of the cell immunity of animals under conditions of oxidation stress and effects of the liposomal drug. Ukrainian Journal of Ecology, 7(4), 536–541. doi: 10.15421/2017_157.

Kotsumbas, H. I., & Hryniv, М. І. (2016). The influence of feed additives on productivity hematological and immunological pa-rameters of the broiler chicks blood. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj, 18, 3(70), 157–160. doi: 10.15421/nvlvet7037.

Lavryshyn, Y. Y., Varkholyak, I. S., Martyschuk, T. V., Guta, Z. А., Ivankiv, L. B., Paladischuk, О. R., Murska, S. D., Gutyj, B. V., & Gufriy, D. F. (2016). The biological significance of the antioxidant defense system of animals body. Scientific Messen-ger LNUVMBT named after S.Z. Gzhytskyj, 18, 2(66), 100–111. doi: 10.15421/nvlvet6622.

Martyshuk, T. V., Gutyj, B. V., & Vishchur, O. I. (2016). Level of lipid peroxidation products in the blood of rats under the influ-ence of oxidative stress and under the action of liposomal prepa-ration of ‘‘Butaselmevit’’. Biological Bulletin of Bogdan Chmelnitskiy Melitopol State Pedagogical University, 6(2), 22–27. doi: 10.15421/201631.

Petrukh, I. M., Simonov, M. R., & Vlizlo, V. V. (2015). Mineralnyi homeostaz u koriv, khvorykh na ketoz, za likuvanni preparatom “Remivital”. Naukovyi visnyk LNU veterynarnoi medytsyny ta biotekhnolohii. Seriia: Veterynarni nauky, 17(2), 183−188. (in Ukrainian).

Saba, A. B., Oyagbemi, A. A., & Azeez, O. I. (2010). Amelioration of carbon tetrachloride-induced hepatotoxicity and haemotoxicity by aqueous leaf extract of Cnidoscolus aconitifolius in rats. Nig. J. Physiol. Sci., 25(2), 139–147.

Skry`pny`k, I. M. (2007). Gepatoprotetorni zasoby` v suchasnij gepatologiyi. Consilium Medicumllkraina, 1(5), 11–15 (in Ukrainian).

Sobolev, А., Gutyj, B., Grynevych, N., Bilkevych, V., & Mashkin, Y. (2017). Enrichment of meat products with selenium by its in-troduction to mixed feed compounds for birds. Regulatory Mechanisms in Biosystems, 8(3), 417–422. doi: 10.15421/021764.

Vlizlo, V. V., Fedoruk, R. S., & Raty`ch, I. B. (2012). Laboratorni metody` doslidzhen` u biologiyi, tvary`nny`cztvi ta vetery`narnij medy`cy`ni: dovidny`k. L`viv: Spolom (in Ukrainian).

Zhukova, I. O., Svitlychna-Kulak, Yu. S., & Longus, N. I. (2016). Correction of stateof antioxidant protection in dogs when poi-soned byneoverm. Scientific Messenger LNUVMBT named after S.Z. Gzhytskyj, 18, 3(70), 95–99. doi: 10.15421/nvlvet7022.
How to Cite
Martyshuk, T., Gutyj, B., Vishchur, O., & Todoriuk, V. (2019). Biochemical indices of piglets blood under the action of feed additive “Butaselmevit-plus”. Ukrainian Journal of Veterinary and Agricultural Sciences, 2(2), 27-30.

Most read articles by the same author(s)