Prevention of hepatosis in laying hens using hepatoprotectors Hep-A-Stress and Hepasan-VS
The article presents the results of preventive efficacy of hepatoprotectors Hep-A-Stress and Hepasan-VS in laying hens with hepatosis. The research was conducted in modern poultry farm. Three groups of laying hens (control and two experimental) Lohmann Brown breed (n = 1500) aged 224 days were formed. The poultry was kept on the main ration according to the technological map for the use of this breed. Laying hens from the first experimental group were additionally given hepatoprotector Hep-A-Stress and the second – Hepasan-VS. Blood sampling for the study was performed three times: before the start of drug administration, after 10 and 30 days from the beginning of hepatorotectors administration. The prophylactic effect of these drugs was determined by studying the preservation and productivity of poultry, interpretation of biochemical analysis of blood serum. The use of hepatoprotectors has allowed to increase the preservation and egg production of laying hens. The results of our studies showed insignificant changes of biochemical parameters in blood after 10 days administration of drugs, which indicates a slow effect of hepatoprotectors on the regenerative processes in the body of poultry. The prophylactic effect was established after 30 days use of hepatoprotectors. Our results showed that the use of these drugs had a positive effect on the protein-synthesizing function of the liver, as indicated by a decrease in serum total protein and an increase a albumin contents. There was also a positive effect on the intensity of protein metabolism, indicated by decreased uric acid and an increased urea in the blood serum of experimental groups. The use of hepatoprotectors helped to reduce the activity of hepatospecific enzymes AST and ALT, which indicates the stabilization of cellular structures of hepatocytes. These drugs have increased the function of bile secretion, which is key of lipid metabolism, as evidenced by an increase in serum cholesterol. Thus, the use of these hepatoprotectors has a positive effect on metabolic processes in the body of laying hens, in particular, normalizes liver function and prevents the development of hepatosis.
Bessarov, B. F., Mel'nykova, Y. Y., Sushkova, N. K., & Sadchyko-va, S. Ju. (2009). Diseases of birds [study guide, 2nd edition]. St. Petersburg: Lan (in Russian).
Burkov, P. V., & Scherbakov, P. N. (2012). The effect of “Geprim for chickens" on the safety and biochemical parameters of blood serum. Bulletin of Altai State Agrarian University, 5(91), 90–92 (in Russian).
Dunets, V. Y., & Slivinska, L. G. (2017). The prevention of liver disease in laying hens. Scientific Messenger of Lviv National University of Veterinary Medicine and Biotechnologies named after S. Z. Gzhytsky, 19(73), 55–60. doi: 10.15421/nvlvet7312 (in Ukrainian).
Dunets, V. Y., & Slivinska, L. G. (2018). Clinical syndromatic of laying hens of breed “Lohmann Brown” in the conditions of farm. Scientific Messenger of Lviv National University of Veteri-nary Medicine and Biotechnologies named after S. Z. Gzhytsky, 20(83), 341–346. doi: 10.15421/nvlvet8368 (in Ukrainian).
Dunets, V. Y., & Slivinska, L. G. (2018). The functional condition of the liver in laying hens under hepatosis. The animal biology, 20(3), 24–29. doi: 10.15407/animbiol20.03.024 (in Ukrainian).
Ermashkevich, E. I., & Kletikova, L.V. (2016). Evaluation of fitokompozitions in chickens with protein liver disease by bio-chemical blood tests. Orel State Gazette, 6(62), 112–117. doi: 10.15217/48484 (in Russian).
Ezhkov, V. O. (2006). Features of metabolic disorders in chickens in industrial conditions poultry breeding. Mater. International NK on the pathophysiology of animals, 57–58 (in Russian).
Kal'berg, N. A., & Sadovnykov, N. V. (2010). The role of the liver in metabolism. Effective poultry farming, 10(70), 39–41 (in Rus-sian).
Katyukha, S. M., Sachuk, R. M., Sousse, G. V., Magrelo, N. V., & Tverdiy, V. M. (2017). New Vitamin and Mineral Preparation “BTF Plus”: Efficiency of Use in the Diet of Broiler Chickens in the Conditions of Personal Farming. Veterinary biotechnology, 30, 89–94 (in Ukrainian).
Kochish, I. I., Petrash, M. G., & Smirnov, S. B. (2004). Poultry. M.: Kolos. (in Russian)
Kuz'minova, E. V., Semenenko, M. P., Starikova, E. A., Tjapkina, E. V. & Fersunin, A. V. (2014). Prospects for expanding the range of hepatoptitectors application in veterinary. Scientific Messenger of Kuban State Agrarian University, 102(08), 787–797 (in Russian).
Lemesheva, M. M., Aisobari, E. E., & Yurchenko, V. V. (2002). Efficiency of using complex feed additives in poultry farming. Bulletin of agrarian science, 42–44 (in Ukrainian).
Melnyk, A. Y. (2014). Prevention of hepatic dystrophy in broiler chickens using the drugs Carnivet L and Vigorpol. Scientific Messenger of Lviv National University of Veterinary Medicine and Biotechnologies named after S. Z. Gzhytsky, 16, 3(60), 235–245 (in Ukrainian).
Melnyk, A. Y. (2015). Analysis and prospects of Ukraine poultry breeding, distribution and classification of poultry metabolic dis-eases. Scientific Messenger of Veterinary Medicine. Bila Tserkva, 2, 67–73 (in Ukrainian).
Melnyk, A. Y. (2017). Some indicators of protein-lipid metabolism and functional state of the liver in broiler chickens using the drug “Alphabet for animals”. Scientific Messenger of Veterinary Med-icine, 2, 69–78 (in Ukrainian).
Melnyk, A. Y., & Ponomar, S. I. (2014). Prevention hepatodystro-phy in broiler chickens with using drugs Karnivet L and Vi-horpol. Scientific Messenger of LNU of Veterinary Medicine and Biotechnologies. Series: Veterinary Sciences, 16(3), 235–244 (in Ukrainian).
Ostapyuk, A., & Gutyj, B. (2019). Influence of cadmium sulfate at different doses on the functional state of the liver of laying chicken. Scientific Messenger of Lviv National University of Vet-erinary Medicine and Biotechnologies. Series: Veterinary sci-ences, 21(94), 103–108. doi: 10.32718/nvlvet9419 (in Ukraini-an).
Sharonina, N. V., Mukhitov, A. Z., & Shishkov, N. K. (2016). Some indicators of metabolism in laying hens when feeding soy okara. Bulletin of the Ulyanovsk State Agricultural Academy, 4(36), 68–71. doi: 10.18286/1816-4501-2016-4-68-71 (in Rus-sian).
Shini, S., & Wayne, L. (2009). Occurrence and control of fatty liver haemorrhagic syndrome (FLHS) in caged hens. Australian egg corporation limited. A report for the Australian еgg сorporation limited, 105, 1–62.
Sokolov, M. N. (2016). On the use of hepatoprotectors in poultry farming. Young scientist, 20, 110–113. https://moluch.ru/archive/124/34137 (in Russian).
Sokolov, V. G., & Ivannikov, S. M. (2013). Clinical and pathomor-phological features of diagnostics hepatosis chickens. Scientific works of the southern branch of the National University of Life and Environmental Sciences of Ukraine “Krim Agrotechnologi-cal University”. Series: Veterinary science, 155, 232–237 (in Russian).
Surai, P. F. (2019). Vitagenes in poultry production: adaptation to commercially relevant stresses. Modern poultry farming. Scien-tific production journal, 07-08(200-201), 28–32 (in Ukrainian).
Thomson, A. E., Gentry, P. A., & Squires, E. J. (2003). Compari-son of the coagulation profile of fatty liver haemorrhagic syn-drome-susceptible laying hens and normal laying hens. British Poultry Science, 44(4), 626–633. doi: 10.1080/00071660310001616228.
Trott, K. A., Giannitti, F., Rimoldi, G., Hill, A., Woods, L., Barr, B., Anderson, M., & Mete, A. (2014). Fatty liver hemorrhagic syn-drome in the backyard chicken: A retrospective histopathologic case series. Veterinary pathology, 51(4), 787–795. doi: 10.1177/0300985813503569.
Yakovleva, L. V., Bezchasnyuk, E. M., Ulesov, A. V., Shapoval, O. N., Khomyakova, L. G., & Zborovskaya, T. V. (2011). L-carnitine: properties, drugs, medical use. Ukrainian Journal of Clinical and Laboratory Medicine, 6(2), 17–24 (in Russian).
Yaremchuk, V., Slivinska, L., & Stronskyi, Y. (2020). Morphologi-cal particulars of the liver of laying hens of breed “Lohmann Brown” under hepatosis. Scientific Messenger of LNU of Veteri-nary Medicine and Biotechnologies. Series: Veterinary Sciences, 22(97), 69–73. doi: 10.32718/nvlvet9712 (in Ukrainian).
Zhang, J., Chen, D., & Yu, B. (2008). Effect of different dietary energy sources on induction of fatty liver-hemorrhagic syn-drome in laying hens. International journal of poultry science, 7(12), 1232–1236.
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