Effects of implant Suprelorin on cytological changes of vaginal epithelial cells in female dogs (4.7 mg deslorelin)

  • T. V. Holumbiyovska Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Pekarska str., 50, Lviv, 79010, Ukraine https://orcid.org/0000-0001-7454-4754
  • V. Y. Stefanyk Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Pekarska str., 50, Lviv, 79010, Ukraine https://orcid.org/0000-0003-2349-4763
  • T. P. Basarab Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, Pekarska str., 50, Lviv, 79010, Ukraine https://orcid.org/0000-0003-1200-2073
Keywords: ovulation, estrus, dog, stimulation of estrus, vaginal cytology, Suprelorin, deslorelin, infertility


Diagnosis of the estrous cycle in female dogs is important in veterinary medicine. The estrous cycle is divided into the following stages: proestrus, estrus, diestrus, metestrus, and anestrus, which due to the action of hormones, replace one after another. This feature of the estrous cycle leads to some difficulties with reproduction. It is hard to obtain newborns because of prolonged anestrus. Vaginal cytology is a simple and available diagnostic method of the estrous cycle. It is based on the analysis of vaginal mucosa epithelial cells changes. This method is used to determine the time of mating and diagnose pathological conditions in the reproductive system of female dogs. There are various drugs in veterinary medicine for the correction of the estrous cycle in female dogs. We used implant Suprelorin® to estrus induction. There were described methods of estrus stimulation using a subcutaneous implant Suprelorin (4.7 mg, deslorelin) and changes in vaginal epithelial cells using the vaginal cytology method. The study was performed on twelve (n = 12) adult female dogs in the anestrus stage. Implants were injected subcutaneously in the groin area and removed at the beginning of the estrus.


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How to Cite
Holumbiyovska, T., Stefanyk, V., & Basarab, T. (2021). Effects of implant Suprelorin on cytological changes of vaginal epithelial cells in female dogs (4.7 mg deslorelin). Ukrainian Journal of Veterinary and Agricultural Sciences, 4(3), 3-10. https://doi.org/https://doi.org/10.32718/ujvas4-3.01